目的探讨散结镇痛胶囊联合复方大血藤灌肠剂治疗子宫内膜异位症的临床疗效。方法选择90例子宫内膜异位症患者按随机数字表分为观察组和对照组各45例,两组患者均行腹腔镜手术。手术后对照组患者给予散结镇痛胶囊治疗,观察组患者在对照组基础上加用复方大血藤灌肠剂灌肠,1个月为1个疗程,连用3个疗程,月经期停用。治疗前、后测定两组患者体液免疫功能、性激素水平和CA125水平,比较两组患者非月经期和月经期的主观症状程度,治疗结束及停药后6个月时比较两组患者的复发情况。结果治疗后观察组患者IgM和IgG水平较对照组患者显著升高,C3水平较对照组患者显著降低,差异均有统计学意义(P<0.01),而两组IgA水平差异无统计学意义(P>0.05)。治疗后观察组患者雌二醇、卵泡刺激素、黄体生成素和CA125水平较对照组患者显著降低,差异均有统计学意义(P<0.01)。治疗后观察组患者非月经周期症状下腹痛、腰痛、排便痛和性交痛评分较对照组患者显著降低,月经周期症状下腹痛、腰痛、排便痛和头痛评分较对照组患者显著降低,差异均有统计学意义(P<0.01)。停药时两组患者均未复发,停药6个月时对照组复发5例,而观察组未有患者复发,差异有统计学意义(P<0.05)。结论散结镇痛胶囊联合复方大血藤灌肠剂可有效预防子宫内膜异位症术后复发,改善患者非月经周期和月经周期主观症状,并且提高患者体液免疫功能及降低体内激素水平。 Objective To investigate the clinical effect of Sanjie analgesic capsule combined with compound Radix Estrogen enema in the treatment of endometriosis. Methods Ninety patients with endometriosis were divided into observation group (45 cases) and control group (45 cases) according to random number table. Laparoscopic surgery was performed in both groups. Patients in the control group were treated with Sanjiezhitong Capsule after operation. The patients in the observation group were given enema on the basis of the control group. One month was 1 course of treatment and 3 courses of treatment were concurrently used. Menstrual phase was discontinued. Before and after treatment, the humoral immunity function, sex hormone level and CA125 level in both groups were measured. The subjective symptoms of non-menstrual period and menstrual period were compared between the two groups. At the end of treatment and at 6 months after discontinuation, the recurrence of the two groups was compared . Results After treatment, the levels of IgM and IgG in the observation group were significantly higher than those in the control group, while the levels of C3 in the observation group were significantly lower than those in the control group (P <0.01). There was no significant difference in IgA and IgG levels between the two groups P> 0.05). After treatment, the levels of estradiol, follicle stimulating hormone, luteinizing hormone and CA125 in observation group were significantly lower than those in control group (P <0.01). In the observation group, the scores of abdominal pain, back pain, defecation pain and painful intercourse were significantly lower than those of the control group in the non-menstrual cycle symptoms, and the scores of lower abdominal pain, back pain, defecation pain and headache in the menstrual cycle symptoms were significantly lower than those in the control group Statistical significance (P <0.01). No drug relapse was found between the two groups when the drug was withdrawn. In the control group, 5 cases relapsed after stopping the drug for 6 months, but no recurrence occurred in the observation group. The difference was statistically significant (P <0.05). Conclusion Sanjie analgesic capsule combined with compound Radix Stemmidum enema can effectively prevent postoperative recurrence of endometriosis, improve non-menstrual cycle and subjective symptoms of menstrual cycle, and improve humoral immune function and reduce hormone levels in the patients.