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鼻咽癌(NPC)在儿童期发病率较低,治疗方式直接影响远期疗效。放疗能对鼻咽原发肿瘤及大多数颈部转移病灶有永久性的控制,但不能阻止远处转移。作者在1980～1982年对16岁以下经病理证实的12例未分化鼻咽癌作了放疗与化疗联合应用的临床观察。其中7男5女,年龄平均为12岁2个月。12例患儿中,1例侵犯口咽,11例有颅底骨质破坏,其中1例合并左侧第6对脑神经瘫痪。全部患儿均有颈部肿块,7例为双侧。治疗方法化疗方案是ADM 40mg/m~2,VCR 1.4mg/m~2,第一天:CTX 20mg/m~2,从第2到第5天;每
The incidence of nasopharyngeal carcinoma (NPC) in childhood is low, and the treatment method directly affects the long-term efficacy. Radiotherapy can permanently control nasopharyngeal primary tumors and most cervical metastatic lesions, but it cannot prevent distant metastases. In 1980 to 1982, the authors compared the clinical application of radiotherapy and chemotherapy in 12 undifferentiated nasopharyngeal carcinomas that were pathologically confirmed under the age of 16. Among them, 7 men and 5 women, with an average age of 12 years and 2 months. Among the 12 cases, 1 case had invaded the oropharynx, and 11 cases had bone destruction at the base of the skull. In 1 case, the left side was the sixth pair of cerebral palsy. All patients had a neck mass and 7 were bilateral. The treatment method for chemotherapy was ADM 40mg/m~2, VCR 1.4mg/m~2, the first day: CTX 20mg/m~2, from the 2nd to the 5th day;