AIM: To investigate the effect of transient ischemia attack(TIA) on phospho-lipid level and the effect of traditional Chinese herb - Yangxueqingnao par-ticles. METHODS: To establish the animal model of TIA in mice by injectingPeroxide through caudal vein, and then feed the mice with Yangxueqingnaoparticles in different dose. After evoking 4 times of TIA and cut off the headthe other day, then measure the level of lysophosphatidic acid(LPA), generalphospholipidin blood plasma and brain tissue. RESULTS: Score of the groupwithout treatment was 1.0±0.8, while that of group administered withYangxueqingnao particles(2 g/kg) was 0.5±0.4(P＜0.05) LPA level ofTIA mice were 6. 1:1±0.4and 2.1±1.3 and increased significantly com-pared with that of the control.This changes can be reversed by treatment as canbe seen the result 4.9±1.6. general phospholipid level of TIA mice in braintissue decreased significantly compared with that of the control as the result:(2.3±1.1) and (6.6±2.8) μmol/g, respectively. After treatment, generalphopholipid level can reach (4.3±2.0) μmol/g.CONCLUSION: LPA andgeneral phospholipid levehin blood plasma and brain tissue are abnorma] inexperimental TIA mice, but can be reversed by Yangxueqingnao particles andit can be used in treatment.