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４０日龄雄性Ｗｉｓｔａｒ大鼠２１只，分为对照（Ｃ）组，腹腔内注射赋形剂和糖尿病（Ｄ）组，腹腔内注射链脲菌素（ｓｔｒｅｐｔｏｚｏｔｏｃｉｎ，ＳＴＺ），５５ｍｇ／ｋｇ体重，观察６０天。结果表明，Ｄ组大鼠的睾丸、附睾、附睾尾重量显著低于Ｃ组（Ｐ＜０．０１）；Ｄ组附睾尾精子计数显著少于Ｃ组（Ｐ＜０．００１）。ＡＣＥ活性测定结果表明，Ｄ组睾丸和附睾尾组织ＡＣＥ活性显著低于Ｃ组（Ｐ＜０．０５），而血清ＡＣＥ显著高于Ｃ组（Ｐ＜０．０１），相关检验显示，附睾重量，附睾尾精子计数与附睾尾ＡＣＥ水平呈显著正相关（Ｐ＜０．０１），与血清ＡＣＥ呈显著负相关（Ｐ＜０．０５，Ｐ＜０．０１）。
Forty-one-day-old male Wistar rats were divided into control group (C), intraperitoneal injection of excipients and diabetes (D), intraperitoneal injection of streptozotocin (STZ), 55 mg / kg body weight 60 days. The results showed that the weights of testis, epididymis and epididymis in group D were significantly lower than that in group C (P <0.01). The spermatozoa in group D were significantly less than those in group C (P <0.001). The results of ACE activity assay showed that ACE activity in testis and epididymal Tissue of group D was significantly lower than that of group C (P <0.05), while serum ACE was significantly higher than that of group C (P <0.01) There was a significant positive correlation between sperm count and epididymal sperm (P <0.01), and negatively correlated with serum ACE (P <0.05, P <0.01).