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本文测定32例健康人和101例流行性出血热(EHF)患者血清超氧化物歧化酶(SOD),丙二醛(MDA)的含量。结果表明EHF患者血清SOD、MDA含量均高于健康对照组,以低血压少尿期升高最为明显。测定中还发现SOD、MDA含量升高与病情变化程度有一定关系。作者认为自由基参与了EHF的发病过程。研究EHF与自由基的关系有助于进一步阐明EHF的发病机理并为其临床治疗提供一定的参考价值。
In this study, the serum levels of superoxide dismutase (SOD) and malondialdehyde (MDA) in 32 healthy individuals and 101 patients with epidemic hemorrhagic fever (EHF) were determined. The results showed that serum SOD and MDA levels in patients with EHF were higher than those in healthy controls, with the most significant increase in hypotension and oliguric phase. The determination also found that SOD, MDA content and the extent of disease changes have a certain relationship. The authors believe that free radicals are involved in the pathogenesis of EHF. The study of the relationship between EHF and free radicals will help further elucidate the pathogenesis of EHF and provide some reference value for clinical treatment.