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目的 :以移植性S180 荷瘤小鼠为实验对象 ,观察具有健脾益气、解毒化瘀、软坚散结功效的中药复方益肝化毒胶囊对S180 荷瘤小鼠IL -Ⅱ、TNF -α的影响。方法 :用S180 腹水型肉瘤小鼠的腹水肿瘤细胞悬液接种小鼠左腋皮下复制肿瘤模型。造模后按体重随机分为模型空白组、肝复乐片组、益肝化毒胶囊小、中、大剂量组、正常对照组。模空组和正常对照组以生理盐水灌胃 ,每日 1次 ,0 2mL·10g-1·d-1;肝复乐片组以肝复乐混悬液灌胃 ,每日 1次 ,0 2mL·10g-1·d-1;益肝化毒胶囊小、中、大剂量组分别以混悬液灌胃 ,每日 1次 ,0 2mL·10g-1·d-1。连续用药 10d ,第 11天取材测定血清IL - 2、TNF -α含量。结果 :本方能提高IL - 2水平 ,并能有效降低异常升高的TNF -α。结论 :益肝化毒胶囊大、中、小剂量均有抗肿瘤作用。
OBJECTIVE: To observe the efficacy of Yiqi Huoxue Capsule, a traditional Chinese medicine with Spleen-enriching Qi, detoxifying and dissolving phlegm, and softening-hardening and dissolving knots on transplanted S180 tumor-bearing mice, to IL-2 and TNF-α in S180 tumor-bearing mice. Impact. METHODS: A mouse model of ascites tumor cell suspension in S180 ascites sarcoma was used to inoculate a mouse model of left subcutaneous tumor replication. After modeling, they were randomly divided into model blank group, Ganfu tablet group, Yigan Huadu Capsule small, medium and large dose group, and normal control group. The empty group and the normal control group were given intragastric administration with normal saline once a day, 0 2mL·10g-1·d-1; the liver-focal tablet group was given intragastrically with Ganfule suspension once daily, 0 2mL·10g-1·d-1; Yigan Huoxue Capsule Small, medium and large dose groups were given intragastrically by suspension once a day, 0 2mL·10g-1·d-1. After 10 days of continuous medication, the serum IL-2 and TNF-α levels were determined on the 11th day. Results : This method can increase the IL-2 level and effectively reduce the abnormally elevated TNF-α. Conclusion: The large, medium and small doses of Yigan Huadu Capsule all have anti-tumor effects.