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目的探讨血尿酸(UA)及相关指标在2型糖尿病并高尿酸血症病情进展中的临床意义。方法以56例2型糖尿病并高尿酸血症和60例2型糖尿病正常尿酸患者为研究对象,测量两组患者的身高、体重、腰围、臀围、血压,检测血尿酸(UA)、血脂(TC、TG、HDL-C、LDL-C)、糖化血红蛋白(HbA1c)、C肽(CP)水平,比较两组血尿酸水平,并分析血尿酸水平与其他指标的关系。结果 2型糖尿病并高尿酸血症组体重指数(BMI)、腰臀比(WHR)、甘油三酯(TG)、糖化血红蛋白(HbA1c)、C-肽(CP)明显高于正常尿酸组(P<0.05),冠心病、高血压病发病率明显高于正常尿酸组(P<0.05),而高密度脂蛋白(HDL-C)低于正常尿酸组(P<0.05)。结论 2型糖尿病并高尿酸血症与肥胖、脂代谢紊乱、胰岛素抵抗、代谢综合征、冠心病、高血压病密切相关,应积极治疗。
Objective To investigate the clinical significance of serum uric acid (UA) and related indicators in the progression of type 2 diabetes mellitus and hyperuricemia. Methods Fifty-six patients with type 2 diabetes mellitus and hyperuricemia and 60 type 2 diabetes normal uric acid patients were enrolled in this study. Height, weight, waist circumference, hip circumference, blood pressure, blood uric acid (UA) TC, TG, HDL-C, LDL-C), HbA1c and C-peptide levels were compared between the two groups, and the relationship between serum uric acid level and other indexes was analyzed. Results Body mass index (BMI), WHR, TG, HbA1c and C-peptide in type 2 diabetes mellitus and hyperuricemia group were significantly higher than those in normal uric acid group (P <0.05). The incidence of coronary heart disease and hypertension was significantly higher than that of normal uric acid group (P <0.05), while HDL-C was lower than that of normal uric acid group (P <0.05). Conclusion Type 2 diabetes mellitus and hyperuricemia are closely related to obesity, lipid metabolism, insulin resistance, metabolic syndrome, coronary heart disease and hypertension, and should be actively treated.