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[目的]探讨胃癌组织中ER、PR、C－erbB－2表达及其临床意义。[方法]应用SP法，对65例胃癌标本进行免疫组化染色。[结果]ER、PR阳性率分别为523.3%和49.2%，阳性率与癌细胞分化程度、浸润深度和淋巴结伴有癌转移呈正相关（P＜0．05）。C-erbB-2阳性率为对23%。阳性率与癌细胞分化程度呈负相关（P＜0.05），与癌浸润深度和淋巴结伴有癌转移呈正相关（P＜0．05）。[结论]ER、PR、C－erbB－2阳性表达的胃癌预后较差。
[Objective] To investigate the expression of ER, PR, C-erbB-2 in gastric carcinoma and its clinical significance. [Methods] 65 cases of gastric cancer specimens were immunohistochemically stained with SP method. [Results] The positive rates of ER and PR were 523.3% and 49.2%, respectively. The positive rate was positively correlated with the degree of differentiation of cancer cells, the depth of invasion, and the metastasis of lymph nodes with cancer (P<0.05). The positive rate of C-erbB-2 was 23%. The positive rate was negatively correlated with the degree of differentiation of cancer cells (P<0.05), and positively correlated with the depth of cancer invasion and lymph node metastasis (P<0.05). [Conclusion] The prognosis of gastric cancer with positive expression of ER, PR and C-erbB-2 is poor.