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目的 比较分析肝硬化所致肝源性糖尿病患者、肝硬化合并Ⅱ型糖尿病患者与单纯原发性Ⅱ型糖尿病患者的血糖、胰岛素、C肽水平及胰岛素敏感性 ,指导临床治疗。方法 肝硬化所致肝源性糖尿病组 15例 ,Ⅱ型糖尿病组 2 0例 ,Ⅱ型糖尿病合并肝硬化组 12例 ,均进行OGTT实验 ,结果进行t检验。结果 肝硬化所致肝源性糖尿病患者胰岛素敏感性好于Ⅱ型糖尿病患者 ;Ⅱ型糖尿病合并肝硬化患者与单纯Ⅱ型糖尿病患者胰岛素敏感性没有差异。结论 肝源性糖尿病患者若应用胰岛素 ,其剂量应相对小 ,并以短效胰岛素为好 ;治疗Ⅱ型糖尿病合并肝硬化时 ,胰岛素应用与单纯Ⅱ型糖尿病没有差异
Objective To compare and analyze the blood glucose, insulin, C-peptide level and insulin sensitivity of patients with liver-derived type 2 diabetes mellitus due to liver cirrhosis, type 2 diabetic patients with cirrhosis and simple type 2 diabetes mellitus, and to guide the clinical treatment. Methods Fifteen cases of liver-derived diabetes mellitus patients with cirrhosis, 20 cases of type Ⅱ diabetes mellitus patients and 12 cases of type Ⅱ diabetes mellitus patients with liver cirrhosis were studied by OGTT and the results were analyzed by t-test. Results The liver sensitivity of patients with liver-derived diabetes mellitus was better than that of patients with type 2 diabetes mellitus. There was no difference in insulin sensitivity between patients with type 2 diabetes mellitus and patients with type 2 diabetes mellitus. Conclusion If insulin is used in patients with liver-derived diabetes, the dose should be relatively small, and short-acting insulin is better. There is no difference between insulin and type 2 diabetes in patients with type 2 diabetes and cirrhosis