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以Framingham心脏研究中的732名无心梗老人(平均年龄78岁,67％为女性)为研究对象,检测外周血α-肿瘤坏死因子(TNFα)、白介素-6(IL-6)和C-反应蛋白(CRP)含量。通过Cox多因素回归分析每种炎症标记物与充血性心力衰竭(CHF)之间的关系。 结果 经过平均5.2年随访,有56例参与者最终发展为CHF。在调查了各种危险因素之后发现,与基线水平比较,TNFα和IL-6与CHF发
A total of 732 unrelated elderly patients (mean age 78 years old, 67% female) from Framingham Heart Study were enrolled in this study. The levels of TNFα, IL-6 and C- Reactive protein (CRP) content. The relationship between each inflammatory marker and congestive heart failure (CHF) was analyzed by Cox multivariate regression. Results After an average follow-up of 5.2 years, 56 participants eventually developed CHF. After investigating various risk factors, it was found that compared with baseline levels, TNFα and IL-6 were associated with CHF