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1940年Katz首先发现致敏家兔血液与相应抗元在体外培育时血小板释放組織胺。1953年Schachter将抗元注入致敏家兔体內也引起組織胺的释放。1955年Humphrey等将純抗元和抗体与悬浮于血浆中的正常家兔血小板一起培育时发现血浆中5—羟色胺及组织胺增加。近年来,很多学者均研究了5—羟色胺和組織胺与过敏反应的关系。
In 1940 Katz first discovered that the sensitized rabbit blood and the corresponding anti-element release of histamine in vitro platelet. In 1953 Schachter injection of anti-element into sensitized rabbits also caused histamine release. In 1955, Humphrey et al. Found that serotonin and histamine were increased in plasma when they were incubated with pure anti-human antibodies and antibodies with normal rabbit platelets suspended in plasma. In recent years, many scholars have studied the relationship between serotonin and histamine and allergic reactions.