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目的:比较分析我院2011、2012年药品不良反应发生(ADR)的特点和区别,以促进临床的合理用药,减少ADR的发生。方法:收集我院2011、2012年的634例ADR监测报告,利用电子表格进行筛选、统计和比较,对药品种类、给药途径、ADR级别、患者年龄与性别、发生部位等进行分析。结果:近两年引起ADR最多仍然是抗菌药物和中药制剂;新的ADR构成比明显降低;青年患者构成比明显增加,中老年患者构成比明显降低;ADR累及器官或系统仍以皮肤及其附件、消化系统最为常见。结论:应加强ADR的监测,合理用药,尤其对中药制剂及抗菌药物应予高度重视。
OBJECTIVE: To compare and analyze the characteristics and differences of adverse drug reaction (ADR) in our hospital from 2011 to 2012 in order to promote clinical rational drug use and reduce the occurrence of ADR. Methods: We collected 634 cases of ADR surveillance reports from 2011 to 2012 in our hospital, and screened, statistically and compared them by electronic form, and analyzed the types of drugs, route of administration, grade of ADR, age and sex of patients, location of occurrence and so on. Results: ADR caused by most of the past two years was still an anti-bacterial drug and traditional Chinese medicine preparation; the new ADR constitutional ratio was significantly lower; young patients’ constitutional ratio was significantly increased, the constitutional ratio of middle-aged and elderly patients was significantly reduced; ADR involved organ or system was still skin and its appendages , Digestive system is the most common. Conclusion: We should strengthen the monitoring of ADR, rational use of drugs, in particular, should pay high attention to traditional Chinese medicine preparations and antimicrobial agents.