神经管畸形(Nerual Tube Defects,NTDs)是神经管发育过程中闭合失败导致的一种先天性畸形,是小儿神经系统的常见畸形,我国每年约有8~10万人次发生。其病因不清,为多因素共同致病,现就其病因及危险因素的研究进展综述如下。一、叶酸因素据统计产妇围孕期补充叶酸可降低70%~90%的神经管畸形发生率[1]。叶酸是豆科植物、新鲜蔬 Nerual Tube Defects (NTDs) is a congenital malformation caused by failure of neural tube during the development of neural tube. It is a common deformity of the nervous system in children. About 80-100,000 people occur annually in China. The etiology is unclear, for multiple factors common disease, now on the etiology and risk factors of research progress are summarized below. First, the factors of folic acid According to statistics maternal peripheral folic acid supplement during pregnancy can reduce the incidence of neural tube defects 70% to 90% [1]. Folic acid is a legume, fresh vegetables