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目的:探讨附睾原发性恶性淋巴瘤的病理特点、临床表现、诊断、鉴别诊断及其治疗。方法:通过光镜观察、免疫组化染色观察1例附睾原发性恶性淋巴瘤,并进行文献复习。结果:临床表现为无痛性附睾肿大。病理诊断为:附睾非霍奇金淋巴瘤(小T淋巴细胞性、低度恶性),睾丸及精索未见肿瘤细胞浸润。免疫组化染色:肿瘤细胞CD45RO、CD3均为强阳性,CD20、CD79α、CK、E-MA、CgA、CD68、胎盘碱性磷酸酶(PLAP)均为阴性。结论:附睾原发性恶性淋巴瘤很少见,根据病理组织学特点及免疫组化染色,并排除附睾慢性炎和肉芽肿性炎等疾病后,可以确诊。
Objective: To explore the pathological features, clinical manifestations, diagnosis, differential diagnosis and treatment of epididymal primary malignant lymphoma. Methods: One case of epididymal malignant lymphoma was observed by light microscope and immunohistochemistry, and the literature review. Results: Clinical manifestations of painless epididymal swelling. Pathological diagnosis: epididymal non-Hodgkin’s lymphoma (small T lymphocytic, low grade), testicular and spermatic cord no tumor cell infiltration. Immunohistochemical staining showed that CD45RO and CD3 of tumor cells were all strongly positive, and all of them were negative for CD20, CD79α, CK, E-MA, CgA, CD68 and placental alkaline phosphatase (PLAP). Conclusion: Epididymis primary malignant lymphoma is very rare. According to histopathological features and immunohistochemical staining and exclusion of chronic epididymitis and granulomatous inflammation, it can be diagnosed.