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目的研究间质表皮转化因子(c-Mesenchymal-epithelial transition factor,c-Met)及磷酸化cMet在肺腺癌组织中的表达,探讨其与肺腺癌发生发展的关系。方法选择经随访资料完整的肺腺癌患者组织标本40例,肺正常对照20例。采用免疫组织化学的方法检测c-Met和磷酸化c-Met(p-Met Tyr1234/1235)在正常肺组织与肺腺癌中的表达情况,并分析其表达与临床特征、病理的关系及两者的相关性。结果 c-Met及pMet在肺腺癌中的阳性表达率高于正常肺组织(P<0.05),两者与患者的年龄、性别、有无吸烟史、肿瘤大小、分化程度无关(P>0.05)。在有淋巴结转移的病例中,c-Met、p-Met皆表达增高(P<0.05)。c-Met与p-Met在肺腺癌组织中表达正相关(r=0.868,P<0.05)。结论 c-Met及p-Met与肺腺癌的发生发展有密切关系,对肿瘤的生物学行为及临床治疗有一定评估作用。
Objective To investigate the expression of c-Met and cMet in human lung adenocarcinoma and to explore its relationship with the development of lung adenocarcinoma. Methods Forty patients with lung adenocarcinoma with complete follow-up data were selected and 20 normal lung controls were included. Immunohistochemistry was used to detect the expression of c-Met and phosphorylated c-Met (p-Met Tyr1234 / 1235) in normal lung and lung adenocarcinoma, and to analyze the relationship between the expression of c-Met and clinical features and pathology The relevance of the person. Results The positive rates of c-Met and pMet in lung adenocarcinoma were significantly higher than those in normal lung tissues (P <0.05). There was no correlation between c-Met and pMet in patients with age, sex, smoking history, tumor size and differentiation ). In cases with lymph node metastasis, both c-Met and p-Met increased (P <0.05). The expression of c-Met and p-Met in lung adenocarcinoma was positively correlated (r = 0.868, P <0.05). Conclusions c-Met and p-Met are closely related to the occurrence and development of lung adenocarcinoma, and have certain evaluation on the biological behavior and clinical treatment of the tumor.