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目的观察生理性起搏联合索他洛尔对病窦综合征(SSS)患者房性快速心律失常的预防作用。方法52例伴严重房性快速心律失常的SSS患者,在植入DDD起搏器1个月后,分为70次/分单纯起搏(A组)、60次/分起搏+索他洛尔80 mg/d(B组)和70次/分起搏+索他洛尔80mg/d(C组)三组,随访治疗8周时自动模式转换(AMS)、高频心房事件(HARE)和连发房早(PACR)的发生次数。结果三组患者的房性快速心律失常均显著下降,AMS、HARE分别下降42%、56%、87%和45%、56%、87%,起搏+药物治疗组(B组或C组)与单纯起搏组(A组)比较差异均有显著性(P<0.05),以C组更明显。结论生理性起搏联合索他洛尔对预防SSS患者的房性快速心律失常有显著作用。
Objective To observe the preventive effect of physiological Pacing combined with Sotalol on atrial tachyarrhythmia in patients with sick sinus syndrome (SSS). Methods Fifty-two SSS patients with severe atrial tachyarrhythmia were divided into 70 pts / min pacing (group A), 60 pts / pacing + sotalol (AMS), atrial fibrillation (HARE), high-frequency atrial fibrillation And the incidence of consecutive room (PACR) the number of occurrences. Results Atrial and ventricular tachyarrhythmia were significantly decreased in all three groups. AMS and HARE were decreased by 42%, 56%, 87% and 45%, 56% and 87% respectively. Pacing + drug treatment group (group B or group C) Compared with simple pacing group (group A), the difference was significant (P <0.05), especially in group C Conclusion Physiological Pacing combined with Sotalol plays a significant role in preventing atrial tachyarrhythmia in patients with SSS.