白细胞介素(IL)在炎症性疾病发病机理中具有重要的作用。其中白细胞介素-6(IL-6)是近年来倍受重视的一种。本文作者对42名婴儿和儿童细菌性脑膜炎患者脑脊液(CSF)和血清进行了IL-6活性的检测,并探讨了IL-6活性与其他炎症性指标及临床预后的关系。 42例细菌性脑膜炎患儿,男23例,女19例,平均年龄2岁半(1月龄～15岁)。所有病例的CSF中均分离出相应的致病菌。36例在入院时(治疗前)抽取CSF标本,其中10例和入院时未采集CSF的6例(共16例),在抗生素治疗过程中分别采取CSF标本。以23例无神经病学体征的发热或发热 Interleukins (IL) play an important role in the pathogenesis of inflammatory diseases. Interleukin-6 (IL-6) is one of the most valued in recent years. The authors tested IL-6 activity in cerebrospinal fluid (CSF) and serum of 42 infants and children with bacterial meningitis and explored the relationship between IL-6 activity and other inflammatory markers and clinical outcomes. 42 cases of bacterial meningitis in children, 23 males and 19 females, mean age 2 years and a half (1 month old to 15 years old). All cases of CSF were isolated from the corresponding pathogens. Thirty-six of the 36 CSF samples were taken at admission (before treatment), 10 of which were CSF-free and 6 were not collected at admission (16 in total). CSF samples were taken during antibiotic treatment. Twenty-three non-neurological signs of fever or fever