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目的:通过对更年期抑郁症模型大鼠行为学以及学习记忆的观察,探讨中药复方更逍遥冲剂的作用机制。方法:SD雌性大鼠40只,随机分为假手术组、更年期抑郁症模型组、中药中剂量组、中药大剂量组和西药对照组,观察开野实验中大鼠活动度、强迫游泳中大鼠的不动时间、以及通道式水迷宫检测大鼠学习记忆能力。结果:模型大鼠经过21d治疗后,开野实验水平积分、垂直积分明显增加,强迫游泳不动时间缩短,水迷宫实验游出时间缩短,错误次数减少。结论:更逍遥冲剂能够明显的改善更年期抑郁症大鼠的行为学评分,并具有改善其学习记忆能力的作用。
OBJECTIVE: To investigate the mechanism of Chinese herbal compound Xiaoyao Ji granules by observing behavior and learning and memory of rats in climacteric depression model. Methods: Forty male Sprague-Dawley rats were randomly divided into sham operation group, model group of menopause depression, middle dose of traditional Chinese medicine, high dose of traditional Chinese medicine and western medicine control group. The activity of rats in open field experiment, Rat immobility time, and channel water maze to detect learning and memory in rats. Results: After 21d treatment, the open field experimental level integral, the vertical integral obviously increased, the forcing swimming immobilization time shortened, the water maze test traveling time shortened, the mistakes times reduced. Conclusion: More Xiaoyao granules can significantly improve the behavioral score of climacteric depression rats, and improve their ability of learning and memory.