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本文报道槲皮素对血小板聚集释放反应以及膜脂质流动性的影响。槲皮素浓度为300μmol时对PAF诱导和600μmol时对凝血酶诱导的大鼠血小板聚集几乎完全抑制;也明显地抑制ADP诱导的大鼠血小板聚集及凝血酶诱导的兔血小板~3H-5 HT释放;在槲皮素浓度为30μmol时,即明显降低血小板膜脂质流动性。
This article reports the effect of quercetin on platelet aggregation and release and membrane lipid fluidity. Quercetin concentration of 300μmol induced almost complete inhibition of thrombin-induced platelet aggregation in PAF-induced and 600μmol-induced rat platelets, and also significantly inhibited ADP-induced platelet aggregation and thrombin-induced 3H-5HT release in rabbit platelets ; Quercetin concentration of 30μmol, that is, significantly reduce platelet membrane lipid fluidity.