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目的 研究肾综合征出血热 (HFRS)疾区类型演变特征及疫苗防制效果。方法 应用血清流行病学方法 ,对连云港市 HFRS疫区演变特征进行监测 ,并根据疫区类型试用单价 HFRS灭活疫苗进行防病效果观察。结果 该市 HFRS疫区在 80年代中期由于汉城病毒 ( 型病毒 )侵入由姬鼠型疫区演变为混合型疫区。本文对二种类型并存的混合型疫区多年流行曲线 ,HFRS病人感染类型和主要宿主动物黑线姬鼠 (Aa) ,褐家鼠 (Rn)季节带毒特征进行了观察 ;试区人群接种 HFRS灭活疫苗连续观察 3年 ,同型特异性保护率为 10 0 %。结论 掌握 HFRS疫区类型演变规律 ,采取相对应防制措施 ,能有效控制HFRS疫情
Objective To study the evolvement characteristics of type of disease and vaccine control effect of hemorrhagic fever with renal syndrome (HFRS). Methods Serological epidemiological methods were used to monitor the evolution characteristics of HFRS epidemic in Lianyungang City. The mononuclear HFRS inactivated vaccine was tested according to the type of endemic area. Results In the mid-1980s, the HFRS epidemic area of the city evolved into a mixed type epidemic area due to the invasion of Seoul virus (type virus) from the ag plague-type epidemic area. In this paper, we observed the multi-year epidemic curves of two types of mixed epidemic areas, the type of HFRS infection and the seasonal poisoning characteristics of main host animals, Apodemus agrarius and Rattus norvegicus (Rn). The experimental population was vaccinated with HFRS Inactivated vaccine for 3 consecutive years of observation, the same type of specific protection rate of 100%. Conclusions Grasp the evolution of HFRS epidemic types, take corresponding control measures, can effectively control the epidemic of HFRS