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[目的]探讨D-二聚体(D-D)、C-反应蛋白(CRP)水平与胫骨骨折内固定术后深静脉血栓形成(DVT)发生率的相关性.[方法]收集本院行胫骨骨折内固定术治疗的患者122例(观察组),另外选择同期在本院健康体检者122例成年人为对照组.比较两组受试者D-D、CRP 水平及不同水平 D-D、CRP 患者的血栓发生率,分析D-D、CRP水平与DVT发生的关系.[结果]观察组患者术后 D-D、CRP 水平显著高于术前,且均显著高于对照组,其差异均有统计学意义(P 600 ug/L、CRP>50 mg/L时,DVT发生率可达到15 %左右.[结论]D-D、CRP水平与胫骨骨折内固定术后 DVT的发生率呈正相关,其可作为DVT发生率的预测指标.“,”[Objective]To investigate the correlation between the levels of D-dimer (D-D)and C-reactive pro-tein (CRP)and the incidence of deep venous thrombosis (DVT)after tibial internal fixation.[Methods]A retro-spective study was conducted.A total of 122 patients of tibial fracture treated by internal fixation in our hospital were selected as the experimental group.In addition,122 healthy adults in the same period were selected as the control group.The D-D and CRP levels in the two groups were compared,and the incidence of thrombosis in D-D and CRP patients at different levels were analyzed to reveal the relationship between D-D and CRP levels and the occurrence of DVT.[Results]The postoperative D-D and CRP levels in the experimental group were significantly higher than those before surgery,and were significantly higher than those in the control group.The differences were statistically significant(P 600 ug/L and CRP>50 mg/L,the incidence of DVT reached about 1 5 %.[Conclusion]The incidence of deep venous thrombosis after the internal fixation of tibial frac-ture is positively correlated with D-D and CRP levels,which can be a clinical predictor for DVT incidence.