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目的:考察用聚四氟乙烯(PTFE)制作相转化水凝胶微针模具的性能。方法:聚四氟乙烯模具经过粉末的过筛、压制、烧结、制孔而得。实验制备了不同聚四氟乙烯粉料粒度、不聚四氟乙烯粉料用料量、不同生料板压制压力的聚四氟乙烯微针模具,向模具中浇注以PVA为基质的聚合物溶液,通过冷冻解冻制得相转化水凝胶微针,考察模具的孔径、载料量以及微针的揭膜难易程度和完形率。结果:80目以上细度的模具透光性能均一;随着聚四氟乙烯用料量的增加和生料板压制压力的增大,模具的孔径和载药量减小,揭膜更容易、完形率更高。结论:聚四氟乙烯模具的性能与其密度密切相关,密度越大的模具,蠕变的随意性越大,因而孔洞均一性下降,但是揭膜性能变好,完形率提高。这两个相反的趋势提示我们,四氟乙烯模具的优劣是相转化水凝胶微针中的第一个控制性因素,聚四氟乙烯是制作微针模具的可接受材料,有进一步研究的价值。
Objective: To investigate the performance of poly (tetrafluoroethylene) (PTFE) for making phase inversion hydrogel microneedles. Method: Teflon mold powder through the sieving, pressing, sintering, hole derived. Experimental preparation of different particle size of PTFE powder, PTFE powder material used, the pressure of different raw materials compressed Teflon microneedle mold, the mold is poured into the PVA-based polymer solution , The phase-converted hydrogel microneedles were obtained by freezing and thawing, and the pore size, loading amount of the mold and the ease of unwinding the microneedles and the rate of complete mold formation were investigated. Results: The transmissivity of the mold with the fineness of more than 80 meshes was uniform. With the increase of the dosage of PTFE and the increase of pressing pressure of the green sheet, the aperture and loading of the mold decreased, Gestalt rate higher. CONCLUSION: The performance of polytetrafluoroethylene mold is closely related to its density. The higher the mold density, the greater the randomness of creep. As a result, the uniformity of the cavity decreases. However, the performance of the mold becomes better and the rate of finished mold is improved. These two opposite trends suggest that the pros and cons of tetrafluoroethylene molds is the first controlling factor in phase transfer hydrogel microneedles and that polytetrafluoroethylene is an acceptable material for making microneedle molds for further research the value of.