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通过固相熔融的方法,使4,4′-联吡啶与磺酸酯或苄溴进行反应.结果表明,将反应固体混合物加热到融化,在30 min内完成反应.通过控制反应物的投料比,可以高选择性的产生单取代或双取代4,4′-联吡啶衍生物.当4,4′-联吡啶与磺酸酯或苄溴摩尔比为1.0∶2.1时,生成双取代产物,收率近100%;当摩尔比为10∶1.0时,生成单取代产物,收率达90%.
4,4’-dipyridyl was reacted with sulfonate or benzyl bromide by solid-phase melting.The results showed that the reaction solid mixture was heated to melt and the reaction was completed within 30 min.Through the control of the feed ratio of the reactants , Can be highly selective monosubstitution or disubstituted 4,4’-bipyridine derivatives when 4,4’-bipyridine and sulfonate or benzyl bromide molar ratio of 1.0: 2.1, the generation of double-substituted products, The yield was nearly 100%. When the molar ratio was 10: 1.0, mono-substituted products were formed in 90% yield.