糖尿病是一个全身代谢性疾病 ,其发病机制涉及很多方面 ,胰岛素抵抗和胰岛 β细胞功能缺陷被认为是其中两个主要环节[1,2 ] 。肥胖、高血压、高脂血症、高尿酸血症和高凝状态构成了胰岛素抵抗的临床症候群。胰岛素抵抗往往在糖耐量减低出现以前就已存在 ,它不仅是导致糖尿病的 Diabetes mellitus is a systemic metabolic disease that involves many aspects of its pathogenesis. Insulin resistance and pancreatic islet beta-cell dysfunction are two of the major linkages considered [1, 2]. Obesity, hypertension, hyperlipidemia, hyperuricemia and hypercoagulability constitute the clinical syndrome of insulin resistance. Insulin resistance often precedes the onset of impaired glucose tolerance, which is not only the cause of diabetes