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目的 研究深低温停循环间断灌注充氧脑保护液对大脑皮层组织丙二醛 (MDA)、血栓素 A2 (TXA2 )及前列环素 (PGI2 )的影响。 方法 杂种犬 10条 ,随机均分为两组。 A组 :单纯深低温停循环 12 0分钟 ;B组 :深低温停循环后间断灌注充氧脑保护液。两组动物分别于不同时相测定大脑皮层组织 MDA,TXA2 的代谢产物血栓素 B2(TXB2 )及 PGI2 代谢产物 6 - Keto- PGF1a的含量。 结果 恢复循环 45分钟后 ,A组 MDA和 TXB2 含量明显高于心肺转流术前 (P<0 .0 1) ,6 - Keto- PGF1a含量明显低于 B组 (P<0 .0 1)。 结论 深低温停循环间断灌注充氧脑保护液能明显减少恢复循环后大脑皮层组织 MDA和 TXA2 的生成 ,增加 PGI2 的生成 ,发挥其对大脑皮层组织的保护作用。
Objective To investigate the effects of intermittent perfusion of oxygenated brain protection solution (CPB) on malondialdehyde (MDA), thromboxane A2 (TXA2) and prostacyclin (PGI2) in the cerebral cortex. Methods 10 hybrid dogs were randomly divided into two groups. Group A: simple deep hypothermic circulatory arrest 120 minutes; Group B: intermittent perfusion after deep hypothermic circulatory arrest and oxygenated brain protective solution. The levels of TXB2, a metabolite of TXA2 and 6 - Keto - PGF1a of PGI2, in cerebral cortex tissue were measured at different time points. Results The content of MDA and TXB2 in group A was significantly higher than that before cardiopulmonary bypass (P <0.01), and the content of 6 - Keto - PGF1a in group A was significantly lower than that in group B after 45 minutes of resumption of circulation (P <0.01). Conclusions Intermittent perfusion of cardioplegic solution with deep hypothermic circulatory arrest can significantly reduce the generation of MDA and TXA2 in the cerebral cortex tissue after recovery from circulation, increase the production of PGI2 and exert its protective effect on cerebral cortex.