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目的:基于DSA探讨高同型半胱氨酸型高血压(H型高血压)与颅内外动脉狭窄的相关性。方法:经DSA检查,纳入有脑血管狭窄的中青年患者72例,同期检查无狭窄的中青年患者42例作为对照组,并将狭窄组根据狭窄程度分为轻、中、重度。记录患者的年龄、高血压、糖尿病、血脂和家族史及是否吸烟等危险因素。于住院后次晨空腹抽取所有受试者的静脉血,采用高效液相色谱法测定血清同型半胱氨酸(Hcy)水平。以Hcy≥10μmol/L作为高同型半胱氨酸血症(HHcy)的标准,高血压伴HHcy者为H型高血压。结果:1.对照组与狭窄组高血压、HHcy患者比较差异无统计学意义,两组H型高血压患者比较P<0.05,差异有统计学意义。2.轻度狭窄组、中度狭窄组及重度狭窄组患者H型高血压发生率的比较有统计学意义。结论:H型高血压是导致颅内外动脉狭窄的危险因素。
Objective: To investigate the relationship between hyperhomocysteinemia (Hypertension) and intracranial and extracranial arterial stenosis based on DSA. Methods: Twenty-two middle-aged and young patients with cerebrovascular stenosis were enrolled in DSA examination. 42 middle-aged and young patients with no stenosis during the same period were selected as the control group. The stenosis group was divided into mild, moderate and severe according to the degree of stenosis. Record the patient’s age, hypertension, diabetes, blood lipids and family history and whether smoking and other risk factors. Venous blood was drawn from all subjects on fasting morning after hospitalization, and serum homocysteine (Hcy) levels were measured by high performance liquid chromatography. With Hcy≥10μmol / L as the standard of homocysteinemia (HHcy), Hypertension with HHcy were Hypertension. There was no significant difference between the control group and the stenosis group, HHcy patients, P <0.05, the difference was statistically significant. The incidence of Hypertension in mild stenosis group, moderate stenosis group and severe stenosis group were statistically significant. Conclusion: Hypertension is the risk factor of intracranial and extracranial artery stenosis.