声嘶的鉴别诊断中除常见的小结、息肉、喉癌外，应包括全身病的局限性喉病变，如特殊性感染、类肉瘤、组织胞浆病、多发性骨髓瘤等。自身免疫性疾病的喉病变致声嘶罕见，如类风湿性环构关节炎（RA）、系统性红斑狼疮（SLE）。SLE患者中约76％有头颈表现，如口粘膜溃疡、鼻中隔 Hoarseness in the differential diagnosis in addition to the common summary, polyps, laryngeal cancer, systemic disease should include the limitations of laryngeal lesions, such as special infections, sarcoid sarcoma, histoplasmosis, multiple myeloma and so on. Laryngeal lesions of autoimmune diseases cause severe hoarseness, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE). About 76% of SLE patients have head and neck manifestations such as mouth ulcers and nasal septum