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目的 观察高度近视LASIK术后应用噻吗洛尔滴眼液的时间长短对屈光回退的影响.方法 前瞻性病例研究.郑州大学第一附属医院2017年1月至2018年12月双眼接受LASIK手术的高度近视32例(64只眼),随机分为临床试验组32例(32只眼)和对照组32例(32只眼),术后每组患者双眼中任选1只眼观察.两组术后常规抗生素滴眼液联合噻吗洛尔滴眼液滴眼,试验组应用噻吗洛尔连滴3个月,对照组应用噻吗洛尔连滴1个月.术后随访6个月.结果 术后1周、1个月两组裸眼视力、眼压、屈光状态的等效球镜度(SE)及角膜前移量差值(Diff值)差异均无统计学意义(P＞0.05),术后3个月及6个月试验组的裸眼视力优于对照组(t=7.030,3.250,P=0.000,0.010),屈光状态(SE)和Diff值均低于对照组(P＜0.05).结论 高度近视LASIK术后应用噻吗洛尔滴眼液时间较长(3个月)者能够较好地预防术后的屈光回退.“,”Objective To observe the effect of application time of Timolol eye drops on refractive regression after LAS1K in patients with high myopia.Methods A prospective case study.The data of 64 eyes of 32 patients with high myopia who underwent LASIK from Jan.2017 to Dec.2018 in the First Affiliated Hospital of Zhengzhou University were analyzed.All cases were randomly divided into the clinical trial group and the control group,32 eyes of 32 cases in each group.All cases were selected one eye after surgery as the observation object.All cases received the conventional antibiotic eye drops combined with Timolol eye drops at 1 day after surgery.The Timolol eye drops in trial group were continuously dripped for 3 months,and the control group were dripped for 1 month.The two groups were followed up for 6 months.Results There was no significant difference in the visual acuity,intraocular pressure,refractive status equivalent spherical degree (SE) and corneal anterior shift (Diff value) between the two groups at 1 week and 1 month after operation(P＞0.05).The difference of uncorrected visual acuity,refractive status (SE) and corneal anterior volume in the clinical trial group at 3 and 6 months after operation were better than those in the control group (t=7.030,3.250,P=0.000,0.010).Conclusion Application of Timolol eye drops after LASIK for 3 months can prevent refractive retraction after high myopia.