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目的观察米菲司酮套装配利凡诺(Rivonol)用于孕13KW～16KW引产的临床效果及安全性。方法观察组122例,米菲司酮采用2日疗法,即第一日早服50mg晚服25mg,第二日方法同第一日,第三日根据情况加用米索前列醇。在第一日服第一次米菲司酮时行羊膜腔内注利凡诺100mg,服米菲司酮时均需服药前后空腹2小时,规定服药时间为早9Am,晚9Pm。常规检查无用药及治疗禁忌症。结果122例均娩一死婴,8例(28～36)h娩一死婴,75例(36～48)h娩一死婴,36例加服米索前列醇后60h娩一死婴,仅一例72h未娩出者行引产加用垂体后叶素娩一死婴,胎盘胎膜剥离。共有6例当时检查胎盘胎膜不完整,行清宫术,术后3日复查B超,有3例宫腔内有异常强回声团,行清宫术,余113例术后3日复查宫腔内均无残留出院。结论米菲司酮套装配利凡诺用于孕13KW～16KW引产临床效果满意,且安全性较好,值得临床推广应用。
Objective To observe the clinical efficacy and safety of Rivarivol for the induction of labor from 13KW to 16KW during pregnancy. Methods Observation group of 122 cases, the use of 2 days therapy, that is, the first day of early serving 50mg 25mg, the second day with the first day, the third day according to the situation with misoprostol. In the first day of the first service when the first intramuscular infusivanone melphalan ketal 100mg, taking both fasting before and after taking two hours, prescribing the medication as early as 9Am, late 9Pm. Routine useless drugs and treatment of contraindications. Results One hundred and twenty-two infants died in one child, eight infants (28-36 h) died in one infancy, 75 infants died in 36-48 h, 36 infants died in 60 h after taking misoprostol, and only one died in 72 h The delivery of labor induction of labor plus pituitary hormone delivery of a dead baby, placental membranes peel. A total of 6 cases were examined placenta fetal membranes incomplete, line curettage, 3 days after the review of B-ultrasound, there are 3 cases of abnormal intrauterine echo group, OK curettage, more than 113 cases of postoperative 3 days review intrauterine No residual discharge. Conclusions Melphalanone suit with rivanol for pregnant 13KW ~ 16KW induction of labor with satisfactory clinical results, and safety is good, worthy of clinical application.