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目的研究多种免疫抑制剂联合治疗激素抵抗型肾病综合征的临床疗效。方法14例患者均接受小剂量环孢素A(CsA)和来氟米特联合中等剂量的强的松治疗,在治疗后第2、4、6、8、12周动态监测各项临床指标。结果24h尿蛋白定量较治疗前明显下降,血浆白蛋白在治疗后明显升高,完全缓解率为64.3%,总有效率为86.7%。结论多靶点治疗激素抵抗型肾病综合征有显著疗效,并且不良反映少,安全性较高。
Objective To study the clinical efficacy of multiple immunosuppressive agents in the treatment of steroid-resistant nephrotic syndrome. Methods Fourteen patients underwent moderate to moderate doses of corticosteroids combined with low-dose cyclosporin A (CsA) and leflunomide. The clinical parameters were monitored dynamically at 2, 4, 6, 8 and 12 weeks after treatment. Results The urinary protein excretion in 24 h was significantly lower than that before treatment. The plasma albumin was significantly increased after treatment. The complete remission rate was 64.3% and the total effective rate was 86.7%. Conclusions Multi-targeted treatment of steroid-resistant nephrotic syndrome has a significant effect, and less adverse reactions, higher safety.