用微量马桑内酯注入Ｗｉｓｔａｒ大鼠左侧前肢运动皮质，造成急性局灶型癫痫。用光镜、电镜和体视学方法研究其运动皮质第Ｖ层结构的改变。结果显示：癫痫大鼠运动皮质灶区、灶旁区的神经细胞数和胶质细胞数均分别比对照大鼠灶区和灶旁区显著减少；灶区神经毡中突触性终末数，显著减少；突触性终末的面积分数明显减少，而树突的面积分数无变化；神经胶质突起的面积分数增加。 Wistar rats injected with trace amounts of corundum left forelimb motor cortex, causing acute focal epilepsy. The changes of V-layer structure of motor cortex were studied by light microscope, electron microscope and stereology. The results showed that the numbers of neurons and glial cells in the motor cortex and psoriasis zone in epileptic rats were significantly decreased compared with those in control rats respectively. The numbers of synaptic terminals, Significantly decreased; the area fraction of synaptic terminals decreased significantly, while the area fraction of dendrites did not change; the area fraction of glial processes increased.