目的观察紫杉醇脂质体配合外照射同期放化疗治疗局晚期鼻咽癌的疗效。方法把病理确诊的63例局部晚期鼻咽癌患者随机分为综合组32例、单纯放疗组31例。两组均采用直线加速器进行放疗,NPTD70-76Gy、预防区域54Gy。综合组在放疗开始给予紫杉醇脂质体同期化疗,每周1次,每次40mg/m2,静脉输入,共5-7次,注射时间为当天放疗前3h。两组分别随访和数据统计。结果综合组和单纯放疗组治疗后原发灶全消率分别为90.30%、58.06%(P<0.05),长期无病生存率提高,综合组的毒性反应亦增加但可耐受。结论加用紫杉醇脂质体每周同期放化疗,可提高局部全消率及长期无病生存率,毒性反应可耐受,为治疗晚期鼻咽癌开创了一条新途径。 Objective To observe the efficacy of paclitaxel liposomes in combination with external irradiation with concurrent radiotherapy and chemotherapy for advanced nasopharyngeal carcinoma. Methods Sixty-three patients with locally advanced nasopharyngeal carcinoma diagnosed by pathology were randomly divided into three groups: 32 cases in combination group and 31 cases in radiotherapy alone group. Both groups were treated with linear accelerator radiotherapy, NPTD70-76Gy, prevention area 54Gy. The combined group was given concurrent paclitaxel liposome chemotherapy at the beginning of radiotherapy once a week for 40mg / m2 intravenously for 5-7 times. The injection time was 3h before radiotherapy. Two groups were followed up and statistics. Results After treatment, the total elimination rate of primary tumor was 90.30% and 58.06% respectively (P <0.05), and the long-term disease-free survival rate was increased. The toxicity of the combination group was also increased but tolerable. Conclusions Weekly paclitaxel liposomes combined with radiotherapy and chemotherapy can improve the local total elimination rate and long-term disease-free survival rate, tolerability of toxic reactions, for the treatment of advanced nasopharyngeal carcinoma to create a new way.