多发性骨髓瘤(MM)为一种浆细胞恶性肿瘤，其发病率较高。MM患者的免疫细胞数量及功能存在明显异常，其中CD4n +T细胞在MM的发生、发展中发挥着重要作用。在MM患者骨髓微环境中，可观察到辅助性T(Th)1/Th2平衡紊乱、调节性T细胞(Treg)增多所致的MM细胞免疫逃逸，以及Th17、Th22等通过分泌细胞因子介导的促肿瘤效应，促进MM的发生、发展。为了加深对MM患者骨髓微环境中CD4n + T细胞亚群作用的理解，从而为MM的免疫治疗提供新思路，笔者在分析MM患者Th1、Th2、Th17、Treg及Th22细胞亚群生物学特征的基础上，重点阐述上述各CD4n + T细胞亚群参与MM发生、发展的研究现状。n “,”Multiple myeloma (MM) is a plasma cell malignancy with high incidence. Quantity and function of immune cells are significantly abnormal in MM patients, and CD4n + T cells play an important role in occurrence and development of MM.In bone marrow environment of patients with MM, balance disorder in helper T cell (Th)1/Th2, immune evasion of MM cells caused by the increase of regulatory T cell (Treg) and tumor-promoting effect mediated by Th17 or Th22 secreted cytokines are observed, and all these promote the occurence and development of MM. In order to deepen the understanding of CD4n + T cell subsets roles in bone marrow microenvironment of MM patients and provide new insights into immunotherapies about MM, this review summaries biological characteristics of CD4n + T cell subsets in MM patients, including Th1, Th2, Treg, Th17 and Th22, and focuses on current research status of CD4n + T cell subsets involvement in occurrence and development of MM patients.n