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目的:探讨急性胰腺炎患者血浆总内皮素(ET)和一氧化氮(NO)与中医血瘀证的关系。方法:设健康人对照组和中医各证型组。采用放免法和反相高效液相色谱测定法分别检测中医各证型组治疗前后血浆ET和亚硝酸盐与硝酸盐(以亚硝酸盐与硝酸盐之和来代表NO水平)。结果:ET及ET/NO在肝脾气滞型无明显变化;在肝脾湿热血瘀型和脾胃实热血瘀型显著增高(P<005或P<001)。结论:ET增高及ET/NO比值增高可能是急性胰腺炎时存在血瘀证的重要客观指标之一。
Objective: To investigate the relationship between plasma total endothelin (ET) and nitric oxide (NO) in patients with acute pancreatitis and blood stasis syndrome. Methods: The healthy control group and TCM syndromes group. The levels of plasma ET and nitrite and nitrate (the sum of nitrite and nitrate to represent the level of NO) were measured by radioimmunoassay and reversed-phase high performance liquid chromatography before and after treatment. Results: There was no significant change of ET and NO in ET model, and there was a significant increase (P <005 or P <001) in damp-heat and blood stasis type of liver and spleen and real blood-stasis type of spleen and stomach. Conclusion: Increased ET and increased ET / NO ratio may be one of the important objective indexes of blood stasis syndrome in acute pancreatitis.