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轮状病毒是世界范围内感染性胃肠炎最常见的病原,每年引起90万人死亡.当前尚无针对该病毒的治疗,方法只限于口服或胃肠道外的补液,据报道有初步迹象表明口服人血清免疫球蛋白有抗轮状病毒作用,作者的目的是了解这种治疗在轮状病毒胃肠炎时是否有效.病例和方法.作者用前瞻性、双盲、安慰剂对照方法进行研究,对98个因急性胃肠炎相继入院的儿童进行登记并随机分为治疗组(A)和对照组(B),A组儿童接受人血清免疫球蛋白300mg/kg,一次口服,B组只接受不含免疫球蛋白的5％葡萄糖.效力参数为临床情况,粪便次数和调度,腹泻的期限,排病毒期限和住院期。抗轮状病毒的效力同免疫球蛋白制剂通过牧民性中和试验方法检测。由不知施用治疗内容的医师根据症状体征作临床评估,对腹泻的治疗包括只含碳酸氢钠和葡萄糖的电解质溶液.常规地于入院时静脉输注,补液量和出院日期由不
Rotavirus is the most common cause of infectious gastroenteritis in the world and causes 900,000 deaths each year.No treatment is currently available for this virus, either oral or parenteral rehydration, and preliminary indications have been reported Oral human serum immunoglobulin has anti-rotavirus effects and the authors aim to understand whether this treatment is effective in rotavirus gastroenteritis.Patients and Methods The authors conducted a prospective, double-blind, placebo-controlled study , 98 children admitted to hospital after acute gastroenteritis were enrolled and randomly assigned to treatment group (A) and control group (B). Children in group A received human serum immunoglobulin 300 mg / kg orally once and group B only Accept 5% dextrose-free glucose The efficacy parameters are clinical, stool frequency and schedule, duration of diarrhea, drowsiness period and hospital stay. Efficacy against rotavirus is tested with immunoglobulin preparations via the herd neutralization assay. Patients who do not know the content of the treatment are clinically evaluated on the basis of symptoms and signs and the treatment of diarrhea includes an electrolyte solution containing only sodium bicarbonate and glucose.The routine infusion of intravenous fluids,