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[目的]了解育龄女性邻苯二甲酸酯的暴露水平,分析其与子宫内膜异位症的相关性。[方法]176名对照和134名子宫内膜异位症患者的病例对照研究,收集研究对象的调查问卷,气相色谱法检测其血清中邻苯二甲酸酯含量。[结果]310例女性血清中的邻苯二甲酸二乙酯(DEP)、邻苯二甲酸二丁酯(DBP)和邻苯二甲酸二(2-乙基-己基)酯(DEHP)检出率分别为15.5%、95.2%和93.5%,几何均数分别为0.062、0.219和0.178mg/L;病例组血清中DBP检出率高于对照组,差异有统计学意义(98.5%vs.92.6%,P<0.05);病例组血清中DBP、DEHP水平高于对照组,差异有统计学意义。其中,DBP为0.304mg/L vs.0.171mg/L,P<0.05;DEHP为0.200mg/L vs.0.163mg/L,P<0.05。多因素logistic回归分析显示,较高的文化程度、有流产史、避孕药服用史、妇科疾病家族史、较高的血清DBP含量可能是与子宫内膜异位症发病有关的危险因素(OR>1,P<0.05)。[结论]邻苯二甲酸酯类化合物的暴露可能与子宫内膜异位症的发病相关。
[Objective] To investigate the level of phthalate exposure in women of childbearing age and analyze its correlation with endometriosis. [Method] A case-control study of 176 controls and 134 endometriosis patients was collected. The questionnaires were collected and the contents of phthalates in serum were determined by gas chromatography. [Results] DEP, DBP and DEHP were detected in 310 female samples The rates of DBP were 15.5%, 95.2% and 93.5% respectively, the geometric mean were 0.062,0.219 and 0.178mg / L, respectively. The detection rate of DBP in case group was higher than that in control group (98.5% vs.92.6 %, P <0.05). The serum levels of DBP and DEHP in the case group were higher than those in the control group, the difference was statistically significant. Among them, DBP was 0.304mg / L vs.0.171mg / L, P <0.05; DEHP was 0.200mg / L vs.0.163mg / L, P <0.05. Multivariate logistic regression analysis showed that higher educational level, history of abortion, taking of contraceptives, family history of gynecological diseases and higher serum DBP levels may be risk factors related to the pathogenesis of endometriosis (OR> 1, P <0.05). [Conclusion] The exposure of phthalates may be related to the pathogenesis of endometriosis.