To investigate the mechanism of the changes in glucocorticoid receptor (GR) under various stress cond experiments were carried out on normal and partial adrenalectomized rats by utilizing radioligand by assay and molecular hybridization. It was found that hepatic GR binding capacity and GR mRNA in mtadecreased significantly after the scalding stress, but the changes in GR binding capacity occurred morer and restored earlier. These results suggest that the reduction of GR binding capacity is mainly owing decrease in GR mRNA levels, and other mechanisms at protein It was found that hepatic GR binding capacity and GR mRNA in mtadecreased significantly After the scalding stress, but the changes in GR binding capacity occurred morer and restored earlier. These results suggest that the reduction of GR binding capacity is primarily owing decrease in GR mRNA levels, and other mechanisms at protein