论文部分内容阅读
目的探讨原发性肝癌(PHC)患者血清中肿瘤坏死因子(TNF-α)、白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平的变化及临床意义。方法采用酶联免疫法检测115例PHC患者治疗前后血清中的TNF-α、IL-2、IL-6和IL-8含量的变化。结果 PHC患者治疗前血清TNF-α、IL-2、IL-6和IL-8水平明显高于正常对照组(P<0.01),治疗后TNF-α、IL-2、IL-6和IL-8水平较治疗前明显下降(P<0.01)。结论联合检测TNF-α、IL-2、IL-6和IL-8水平的动态变化对PHC的临床诊断、疗效评价和预后判断有重要意义。
Objective To investigate the changes of serum tumor necrosis factor (TNF-α), interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 -8) levels and clinical significance. Methods Serum levels of TNF-α, IL-2, IL-6 and IL-8 in 115 patients with PHC were measured by enzyme-linked immunosorbent assay. Results The levels of TNF-α, IL-2, IL-6 and IL-8 in serum of patients with PHC before treatment were significantly higher than those of normal control group (P <0.01) 8 levels were significantly lower than before treatment (P <0.01). Conclusion The combined detection of TNF-α, IL-2, IL-6 and IL-8 levels in the dynamic changes of PHC clinical diagnosis, efficacy evaluation and prognosis of great significance.