目的　研究癫痫病人的生活质量及其影响因素 ,为进一步治疗提供线索 ,以提高病人生活质量。方法　用癫痫病人生活质量量表 30 (QOLIE 30 )对 10 6例临床确诊的成人癫痫病人和 6 4名对照进行评定。结果　癫痫组较对照组生活质量明显降低 [QOL得分分别为 5 4± 16和 77± 15 ],表现在惧怕发作 ,对日常生活不满意 ,情绪差 ,精力不足 ,认知功能下降 ,对长期服用抗癫痫药物的顾虑较多 ,社交、工作受限等。不同性别、不同病程、不同用药数量、不同发作频率病人的生活质量比较 ,用药和发作频率对生活质量影响较大 ,QOL与用药数量呈负相关 ,与发作频率负相关。结论　癫痫病人生活质量明显降低 ,用药和发作频率对生活质量影响较大 ,合适的药物控制癫痫发作是提高癫痫病人生活质量的关键。 Objective To study the quality of life and its influencing factors in patients with epilepsy and provide clues for further treatment in order to improve the quality of life of patients. Methods A total of 106 clinically diagnosed adults with epilepsy and 64 controls were assessed using the Quality of Life Epileptic Scale 30 (QOLIE 30). Results The quality of life of epilepsy group was significantly lower than that of the control group [QOL scores were 54 ± 16 and 77 ± 15, respectively], showing a fear of attack, dissatisfaction with daily life, poor mood, lack of energy, decreased cognitive function, long-term use Antiepileptic drugs more concern, social, work restrictions and so on. The quality of life of patients with different genders, different duration of disease, different doses and different seizure frequency had a greater impact on the quality of life. QOL was negatively correlated with the amount of medication and negatively correlated with seizure frequency. Conclusion The quality of life of patients with epilepsy is significantly reduced, the frequency of medication and seizure have a greater impact on the quality of life, and the appropriate medication to control seizures is the key to improve the quality of life of patients with epilepsy.