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目的探讨妊娠期高血压疾病患者胎盘组织中水通道蛋白1(aquaporins1,AQP1)的表达情况及意义。方法选择2010年8月至2011年4月在北京军区总医院住院分娩的妊娠期高血压疾病患者共44例(妊娠期高血压疾病组),其中妊娠期高血压孕妇15例(妊娠期高血压组),轻度子痫前期孕妇14例(轻度子痫前期组),重度子痫前期孕妇15例(重度子痫前期组);以同期正常晚期妊娠妇女16例为对照组。采用免疫组织化学方法检测各组孕妇胎盘组织中AQP1表达水平。结果妊娠期高血压疾病组与对照组比较胎盘组织中AQP1表达明显增强,差异有极显著性(U=2.661,P<0.01),妊娠期高血压组、轻、重度子痫前期组间AQP1表达逐渐增强,差异有显著性(P<0.05)。结论 AQP1在妊娠期高血压疾病患者尤其是在重度子痫前期患者胎盘组织中的表达升高可能与妊娠期高血压疾病的发生发展密切相关。
Objective To investigate the expression and significance of aquaporins 1 (AQP1) in placenta of patients with gestational hypertension. Methods Forty-four patients with gestational hypertension (gestational hypertension group) were hospitalized in Beijing Military General Hospital from August 2010 to April 2011. Among them, 15 were pregnant women with gestational hypertension (gestational hypertension Group), 14 pregnant women with mild preeclampsia (mild preeclampsia group) and 15 pregnant women with severe preeclampsia (severe preeclampsia group); 16 women with normal late pregnancy as the control group. Immunohistochemistry was used to detect the expression of AQP1 in placenta of each group. Results Compared with control group, the expression of AQP1 in gestational hypertension group was significantly higher than that in control group (U = 2.661, P <0.01). The expression of AQP1 in gestational hypertension group, mild and severe preeclampsia group Gradually increased, the difference was significant (P <0.05). Conclusion The elevated expression of AQP1 in patients with gestational hypertension, especially in patients with severe preeclampsia, may be closely related to the occurrence and development of hypertensive disorder complicating pregnancy.