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目的探讨北京市丰台区2013年D8基因型麻疹流行的主要危险因素。方法运用Cox回归模型拟合1∶2配对条件logistic回归模型,分析探索D8基因型麻疹发生的危险因素。结果共调查16组(48名)研究对象,单因素分析结果表明,户籍、合租合住、到过服装批发市场与D_8基因型麻疹发病有关(P<0.05)。多因素分析结果表明,到过服装批发市场者发生D8基因型麻疹的优势比(Odds Ratio,OR)值为10.95(95%CI:1.16~102.96),P<0.05;外省户籍发病风险高于该市户籍(OR:6.09,95%CI:1.09~34.11)。结论到过服装批发市场、外省户籍是丰台区D_8基因型麻疹发生的危险因素;通过加强麻疹病毒基因型监测,有助于追溯传染源,及时发现可疑影响因素。
Objective To explore the main risk factors for the epidemic of D8 genotype in Fengtai District of Beijing in 2013. Methods Cox regression model was fitted to 1: 2 logistic regression model to explore the risk factors of D8 genotype. Results A total of 16 subjects (48 subjects) were investigated. The results of univariate analysis showed that the incidence of D_8 genotype was associated with the incidence of household registration, sharing rent and living together and the wholesale clothing market. Multivariate analysis showed that the Odds Ratio (OR) values of D8 genotypes to clothing wholesalers were 10.95 (95% CI: 1.16-102.96), P <0.05; the incidence of domicile in other provinces was higher than that of City household registration (OR: 6.09, 95% CI: 1.09 ~ 34.11). Conclusion In the clothing wholesale market, the household registration in other provinces is a risk factor for the genotype D_8 in Fengtai District. By monitoring the genotypes of measles virus, it is helpful to trace the source of infection and find the suspicious influencing factors in time.