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高龄或曾接受大量化疗的非何杰金淋巴瘤患者一般情况较差,预后不良,对化疗耐受性下降。为此,作者欲探索一种可减少骨髓和胃肠遭毒性而治疗有效的药物治疗方法,采用每周一次小剂量化疗方案,但发生意想不到的严重肺部毒性。 19例非何杰金淋巴瘤中,5例未接受过化疗,年龄超过60岁;14例接受过强力化疗后复发,年龄41～82(中位数65)岁。2例低度分化淋巴瘤,13例中度分化淋巴瘤,4例高度分化淋巴瘤。每周间歇用药1次,治疗2～12(中位数8)周,第1、3、5、7,9、11周静注二羟蒽二酮(mitoxantrone)8mg/M~2和环磷酰胺375mg/M~2,第2、4、6、8、10、12周注射争光霉素10U/M~2和长春新碱1.4mg/M~2,化疗期间每天口服强的松龙40mg。 5例开始化疗后存活6～17个月,其中2例仍保持部分缓解,3例完全缓解后复发。统计11例中,3例(27％)完全缓解,7例(64％)部分缓解。6例
Patients with advanced or previously untreated Hodgkin’s lymphoma who have received extensive chemotherapy have generally poor prognosis and poor tolerance to chemotherapy. To do this, the authors sought to find a therapeutically effective drug that would reduce bone marrow and gastrointestinal toxicity using a low-dose chemotherapy regimen once a week but with unexpectedly severe lung toxicity. Of the 19 non-Hodgkin lymphoma cases, 5 had not received chemotherapy and were over 60 years of age; 14 had relapsed after intensive chemotherapy and were 41 to 82 years (median 65 years). 2 cases of poorly differentiated lymphoma, 13 cases of moderately differentiated lymphoma and 4 cases of highly differentiated lymphoma. Weekly intermittent medication 1, treatment 2 to 12 (median 8) weeks, 1,3,5,7,9,11 week intravenous injection of dihydroxyanthrene (mitoxantrone) 8mg / M ~ 2 and cyclic phosphorus Amide 375mg / M ~ 2, 2,4,6,8,10,12 weeks injection of bleomycin 10U / M ~ 2 and vincristine 1.4mg / M ~ 2, daily oral prednisolone 40mg. Five patients survived 6 to 17 months after starting chemotherapy, of which 2 remained partially relieved and 3 relapsed after complete remission. Of the 11 cases, 3 (27%) were completely relieved and 7 (64%) were partially relieved. 6 cases