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目的:探讨LEEP在宫颈上皮内瘤变(CIN)临床应用的安全性及有效性。方法:回顾性分析45例CIN患者治疗的临床资料。结果:45例LEEP手术过程中,患者无特殊不适,手术时间平均10±5 min,术中出血平均15±5 mL。术后病理报告与术前诊断相比完全符合18例,一致率为40%;病理升级13例,比率为28.89%;病理降级14例,比率为31.11%。其中16例LEEP患者再次行筋膜外子宫全切术,术后病检均未见到CIN的残留。1年后随访发现,16例经LEEP及筋膜外子宫全切术后,复查无异常,达到治愈。29例经单纯LEEP治疗后,27例治愈,2例治疗无效,再次行LEEP手术及药物治疗好转。结论:LEEP治疗CIN,安全有效,价格实惠,手术时间短,患者疼痛小,出血少,并且能够保留完整、连续的标本进行病检,明显降低CIN的漏诊率,值得临床应用。
Objective: To investigate the safety and efficacy of LEEP in the clinical application of cervical intraepithelial neoplasia (CIN). Methods: The clinical data of 45 patients with CIN were retrospectively analyzed. Results: During 45 cases of LEEP, there was no particular discomfort in the patients. The average operation time was 10 ± 5 minutes and the intraoperative bleeding was 15 ± 5 mL. The postoperative pathological reports were consistent with the preoperative diagnosis of 18 cases, the coincidence rate was 40%; pathological upgrade in 13 cases, the rate was 28.89%; pathological degradation in 14 cases, the rate was 31.11%. Among them, 16 cases of LEEP underwent extrafascial hysterectomy again, and no residual CIN was found in postoperative pathological examination. Follow-up 1 year later found that 16 cases of LEEP and fascia extra-uterine hysterectomy, the review no abnormalities, to cure. Of the 29 patients treated with LEEP alone, 27 were cured and 2 were ineffective. LEEP and drug therapy were performed again. Conclusions: LEEP is safe and effective, affordable, short operative time, small pain, less bleeding, and can retain complete and continuous specimens for pathological examination, which significantly reduces the rate of misdiagnosis of CIN and is worthy of clinical application.