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目的:探讨血管内皮生长因子(VEGF)及受体-1(sFlt-1)在正常妊娠及子痫前期孕妇血清中水平与妊娠结局的关系。方法:采用酶联免疫吸附试验(ELISA)法测定30例子痫前期患者(其中轻度11例,重度19例)的外周血(静脉血)VEGF、sFlt-1,并与30例正常孕妇作对照。结果:子痫前期孕妇血清中VEGF水平比正常对照组低,sFlt-1水平比正常对照组高(P<0.01),重度子痫前期孕妇血清中VEGF水平比轻度低,sFit-1水平比轻度高(P<0.05)。比较子痫前期孕妇与正常孕妇的妊娠结局,两者在分娩孕周、宫高、腹围、胎儿双顶径、新生儿体重1 min Apgar评分、羊水Ⅱ~Ⅲ污染度、胎盘重量均存在差异。结论:子痫前期患者血清中VEGF、silt-1水平的改变会引起内皮细胞激活和损伤,从而导致高血压、蛋白尿等临床症状,并对围产儿的结局有一定影响。
Objective: To investigate the relationship between the serum level of vascular endothelial growth factor (VEGF) and receptor-1 (sFlt-1) in pregnant women with normal pregnancy and preeclampsia and pregnancy outcome. Methods: The levels of VEGF and sFlt-1 in peripheral blood (venous blood) of 30 preeclampsia patients (11 mild and 19 severe) were measured by enzyme linked immunosorbent assay (ELISA) and compared with 30 normal pregnant women . Results: Serum levels of VEGF in pregnant women with preeclampsia were lower than those in normal control group, sFlt-1 level was significantly higher than that in normal control group (P <0.01), serum VEGF level in preeclampsia was lower than that in mild preeclampsia group and sFit-1 level Mildly high (P <0.05). The pregnancy outcomes of preeclampsia and normal pregnant women were compared. There were differences in gestational age, uterine height, abdominal circumference, biparietal diameter, 1-minute Apgar score, amniotic fluid II-III levels and placental weight . Conclusion: The changes of serum VEGF and silt-1 levels in preeclampsia may induce the activation and injury of endothelial cells, leading to clinical symptoms such as hypertension and proteinuria, which may affect the outcome of perinatal infants.