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目的 探讨血浆内皮素 (ET)在鱼胆中毒患者的变化及其与鱼胆中毒后多器官功能障碍综合征 (MODS)发生及发展的关系。方法 采用放射免疫法测定 85例鱼胆中毒患者与 3 0名健康人血浆ET水平 ,比较鱼胆中毒各组间血浆ET水平 ,分析鱼胆中毒患者血浆ET水平与血清酶学、血生化等指标的关系。结果 鱼胆中毒患者血浆ET水平 (150 5± 90 5)ng/L较正常对照组 (52 8±9 3 )ng/L明显升高 (P <0 0 1) ,轻度中毒组血浆ET水平 (61 2± 13 6)ng/L与正常对照组比较 ,差异无显著性 (P >0 0 5) ,中度与重度中毒组血浆ET水平 (162 3± 82 3 )ng/L ,(2 3 2 6± 92 7)ng/L较正常对照组明显升高 (P值均 <0 0 1) ,中度中毒组血浆ET水平高于轻度中毒组 (P <0 0 1) ,重度中毒组又高于中度中毒组 (P <0 0 1)。MODS组与非MODS组血浆ET水平 (2 10 2± 98 7)ng/L ,(12 6 3± 68 3 )ng/L均显著高于对照组 (P <0 0 1) ,MODS组血浆ET水平又高于非MODS组 (P <0 0 1)。血浆ET与肌酸激酶同工酶、心肌肌钙蛋白I、乳酸脱氢酶、ALT、AST、血尿素氮、血肌酐呈显著正相关 (P <0 0 1或 0 0 5) ,与肌酐清除率呈显著负相关 (P <0 0 1)。死亡组血浆ET水平 (2 53 5± 96 7)ng/L明显高于非死亡组 (159 3± 67 9)ng/L(P <0 0 1)。 ?
Objective To investigate the changes of endothelin (ET) in fish gallbladder poisoning and its relationship with the occurrence and development of multiple organ dysfunction syndrome (MODS) after fish gall intoxication. Methods Plasma ET levels in 85 cases of fish gall bladder poisoning and 30 healthy people were determined by radioimmunoassay. Plasma endothelin (ET) levels were compared between groups of fish gallstone poisoning. The levels of plasma ET, serum enzymes and blood biochemistry were analyzed Relationship. Results The plasma endothelin (ET) level of 150 ± 90 5 ng / L in fish poisoning patients was significantly higher than that of normal controls (52 8 ± 9 3) ng / L (P 0 01) (61 ± 13 6) ng / L compared with the control group, there was no significant difference between the two groups (P> 0.05), while the levels of ET in the moderate and severe poisoning groups were (162 3 ± 82 3) ng / L, (2 3 2 6 ± 92 7) ng / L was significantly higher than that of the normal control group (all P 0 01). The plasma ET level of moderate poisoning group was higher than that of mild poisoning group (P 0 01) The group was higher than the moderate poisoning group (P <0.01). The levels of ET in MODS group and non-MODS group were significantly higher than those in control group (2 10 2 ± 98 7) ng / L and (12 6 3 ± 68 3) ng / L, respectively The level was higher than the non-MODS group (P <0.01). Plasma ET was positively correlated with creatine kinase isoenzyme, cardiac troponin I, lactate dehydrogenase, ALT, AST, blood urea nitrogen and serum creatinine (P <0.01 or 0.05), but not with creatinine clearance There was a significant negative correlation (P <0.01). The level of ET in the death group was significantly higher than that of the non-death group (23 537 ± 99 7 ng / L, P <0.01). ?