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目的 观察银杏叶提取物 (GBE)和银杏叶提取物合剂 (GBEM)对动脉粥样硬化斑块面积的影响并探讨其可能机理。方法 将 30只家兔随机分成正常对照组、高胆固醇组、GBE保护组、低剂量GBEM保护组、高剂量GBEM保护组 ,后 4组加喂养 1%高胆固醇 ,后 3组再分别加喂 0 .5g/ (kg·d)GBE、1.0g/ (kg·d)GBEM、3.0g/ (kg·d)GBEM。 12w后 ,处死各组家兔 ,测量胸主动脉AS斑块面积 ,分析血脂成分 ,测量丙二醛、一氧化氮的浓度。结果 与高胆固醇组相比 ,GBE保护组和高剂量GBEM保护组的胸主动脉动脉粥样硬化斑块面积 (% )显著要小 (P <0 .0 1) ,GBE保护组的载脂蛋白AI明显要高 (P <0 .0 5) ,高剂量GBEM保护组的总胆固醇显著要低 (P <0 .0 1) ,高剂量GBEM保护组的甘油三酯、低密度脂蛋白、载脂蛋白AI明显要低(P <0 .0 5) ,GBE保护组、低剂量GBEM保护组、和高剂量GBEM保护组的丙二醛明显要低 (P <0 .0 5) ,一氧化氮明显要高 (P <0 .0 5)。结论 GBE、高剂量GBEM可能通过降低血脂、抗氧化、增加一氧化氮的含量来减少动脉粥样硬化斑块面积。
Objective To observe the effect of ginkgo biloba extract (GBE) and ginkgo biloba extract mixture (GBEM) on the area of atherosclerotic plaque and to explore its possible mechanism. Methods Thirty rabbits were randomly divided into normal control group, high cholesterol group, GBE protection group, low-dose GBEM protection group and high-dose GBEM protection group. After 4 rabbits were fed with 1% cholesterol, the latter 3 groups were fed with 0 GBE, 1.0 g / (kg · d) GBEM, 3.0 g / (kg · d) GBEM. After 12 weeks, the rabbits in each group were sacrificed and the plaque area of the thoracic aorta was measured. The lipids were analyzed to measure the concentration of malondialdehyde and nitric oxide. Results Compared with the high cholesterol group, the areas of atherosclerotic plaque in the thoracic aorta (GBE group and high-dose GBEM group) were significantly smaller (P <0.01), those in the GBE group AI was significantly higher (P <0.05), total cholesterol was significantly lower in high-dose GBEM protection group (P <0.01), high-dose GBEM protection group triglyceride, low density lipoprotein, The protein AI was significantly lower (P <0.05). The levels of malondialdehyde in GBE protection group, low-dose GBEM protection group and high-dose GBEM protection group were significantly lower (P <0.05) Higher (P <0 .05). Conclusion GBE and high-dose GBEM may reduce the area of atherosclerotic plaque by decreasing blood lipid, anti-oxidation and increasing nitric oxide.