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目的 研究家族高发性2型糖尿病家系人群中可能的遗传和环境危险因素。方法 对1999～2001年门诊及住院的125个家庭高发性2型糖尿病先证者的家庭成员调查家族信息和环境危险因素,比较2型糖尿病患者、糖耐量减低(IGT)患者与非患者在环境危险因素的差异。采用Falconer法估算遗传度,用Penrose法进行多基因分析研究其遗传危险性。结果 三组人群甘油三酯、体重指数、腰臀比值、高血压史及体力活动史的构成比差异有极显著性(P<0.01),而其他血脂项目及冠心病史差异未见显著性。125个大家系的2型糖尿病遗传度为83.42％±5.84％,提示在这些家系中可能有显性主基因存在。多基因分析研究表明在该人群中,2型糖尿病可能符合多基因遗传模式。结论 2型糖尿病为多基因疾病,环境危险因素和遗传因素及其交互作用可能影响其发病。
Objective To study the possible genetic and environmental risk factors in familial population of type 2 diabetics. Methods Family members of 125 family members with high incidence of type 2 diabetes mellitus in outpatients and inpatients from 1999 to 2001 were surveyed for familial information and environmental risk factors. Patients with type 2 diabetes, impaired glucose tolerance (IGT) and non-patients Differences in risk factors. The Falconer method was used to estimate the heritability and the Penrose method was used to analyze the genetic risk. Results There were significant differences in the constituent ratios of triglyceride, body mass index, waist-hip ratio, history of hypertension and physical activity among the three groups (P <0.01), but no significant differences were found in the other lipid items and the history of coronary heart disease. The heritability of type 2 diabetes in 125 major pedigrees was 83.42% ± 5.84%, suggesting that dominant gene may exist in these pedigrees. Multivariate analysis shows that in this population, type 2 diabetes may be multi-genetically inherited. Conclusions Type 2 diabetes is a polygenic disease. Environmental risk factors, genetic factors and their interactions may affect their pathogenesis.