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非酒精性脂肪肝(Nonalcoholic fatty liver disease,NAFLD)发病率日益增加且可发展为肝硬化,最后导致肝脏衰竭而死亡[1]。肝细胞色素P450(Cytochrome P450,CYP)是肝脏混合功能氧化酶中的氧化酶系,在肝脏中含量最丰富[2]。CYP2E1催化肝毒性物代谢时能减少分子氧同时产生前氧化物
The incidence of nonalcoholic fatty liver disease (NAFLD) is increasing and it can develop into liver cirrhosis, leading to liver failure and death [1]. Cytochrome P450 (CYP) is an oxidase system in the liver mixed-function oxidase, which is the most abundant in the liver [2]. CYP2E1 catalyzes the metabolism of hepatotoxic substances to reduce molecular oxygen while producing preoxide