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目的探讨成人神经母细胞瘤(adult neuroblastoma ANB)的临床病理特点、诊断及鉴别诊断。方法回顾盛京医院诊治的4例ANB的临床、病理特征及免疫表型特点。结果 4例ANB患者发病年龄22～33岁,男女比例3∶1。临床主要表现为胸腹部包块、隐痛不适。形态学及免疫表型与小儿NB表现相同:瘤细胞圆形深染,大小较一致,可见坏死及钙化。瘤细胞表达NSE、NF、Syn。结论 ANB是一种极少见的恶性肿瘤,预后差,在临床和病理诊断时要考虑到此病的可能性。
Objective To investigate the clinicopathological characteristics, diagnosis and differential diagnosis of adult neuroblastoma ANB. Methods The clinical, pathological features and immunophenotypic features of 4 cases of ANB diagnosed and treated in Shengjing Hospital were reviewed. Results The incidence of ANB in 4 patients was 22-33 years old, with a ratio of 3: 1. Clinical manifestations of chest and abdomen mass, pain and discomfort. Morphology and immunophenotype with the same performance of pediatric NB: tumor cells with deep stained, the size of more consistent, visible necrosis and calcification. Tumor cells express NSE, NF, Syn. Conclusion ANB is a rare malignant tumor with poor prognosis. It is considered in the clinical and pathological diagnosis of the possibility of this disease.