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目的：探讨血浆中不对称二甲基精氨酸（ＡＤＭＡ）浓度与妊娠高血压综合征（妊高征）的关系。方法：应用高效液相色谱法测定２０例正常妊娠妇女及２６例妊高征患者的血浆ＡＤＭＡ水平。结果：（１）妊高征患者血浆ＡＤＭＡ水平为（１．４５±０．３６）μｍｏｌ／ Ｌ，正常妊娠组ＡＤＭＡ水平为（０．８３±０．２８）μｍｏｌ／ Ｌ，两组间比较，差异显著（Ｐ＜０．０５）。（２）妊高征组ＡＤＭＡ水平与平均动脉压呈明显正相关（ｒ＝０．６７，Ｐ＜０．０１）。结论：血浆中ＡＤＭＡ水平与妊高征关系密切，可能在妊高征的发病和防治中具有重要的生理病理意义。
Objective: To investigate the relationship between asymmetric dimethylarginine (ADMA) concentration and pregnancy induced hypertension (PIH) in plasma. Methods: Plasma ADMA levels were measured in 20 normal pregnant women and 26 patients with PIH using high performance liquid chromatography. Results: (1) The level of plasma ADMA in PIH patients was (1.45 ± 0.36) μmol / L, while the level of ADMA in normal pregnancy was (0.83 ± 0.28) μmol / L, The difference was significant (P <0.05). (2) The level of ADMA in PIH group was positively correlated with mean arterial pressure (r = 0.67, P <0.01). Conclusion: There is close relationship between plasma ADMA level and PIH, which may have important physiological and pathological significance in the pathogenesis and prevention of PIH.